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Article

Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1.

eLife - 13 May 2020

Madel Maria-Bernadette, Ibáñez Lidia, Ciucci Thomas, Halper Julia, Rouleau Matthieu, Boutin Antoine, Hue Christophe, Duroux-Richard Isabelle, Apparailly Florence, Garchon Henri-Jean, Wakkach Abdelilah, Blin-Wakkach Claudine

Abstract excerpt

Bone destruction relies on interactions between bone and immune cells. Bone-resorbing osteoclasts (OCLs) were recently identified as innate immune cells activating T cells toward tolerance or inflammation. Thus, pathological bone destruction not only relies on increased osteoclast differentiation, but also on the presence of inflammatory OCLs (i-OCLs), part of which express Cx3cr1. Here, we investigated the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32400390
DOI: 10.7554/eLife.54493
PMCID: PMC7220377

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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