Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Programmed Death-1 Pathway Counter-Regulates Inflammation-Induced Osteoclast Activity in Clinical and Experimental Settings

9 Mar 2022

Abstract excerpt

Objective The programmed death-1 (PD-1) pathway is essential for maintaining self-tolerance and plays an important role in autoimmunity, including rheumatoid arthritis (RA). Here, we investigated how membrane-bound and soluble (s)PD-1 influence bone homeostasis during chronic inflammation, exemplified in RA. Methods Bone mineral density and bone microstructure were examined in PD-1 and PD-L1 knockout (KO) mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone health and osteoporosis research
Share to Bone Metabolism and Diseases
Share to Rheumatoid Arthritis Research and Therapies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35356000
DOI: 10.3389/fimmu.2022.773946

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Programmed Death-1 Pathway Counter-Regulates Inflammation-Induced Osteoclast Activity in Clinical and Experimental SettingsPMID 35356000Read ↗

The deficiency of immunoregulatory receptor PD-1 causes mild osteopetrosis.Semantic proximity Read ↗

New regulation mechanisms of osteoclast differentiationSemantic proximity Read ↗

Biology of the RANKLâ€“RANKâ€“OPG System in Immunity, Bone, and BeyondSemantic proximity Read ↗

Monocytic MDSCs skew Th17 cells toward a pro-osteoclastogenic phenotype and potentiate bone erosion in rheumatoid arthritis.Semantic proximity Read ↗

DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice.Semantic proximity Read ↗

RANK-L and RANK: T Cells, Bone Loss, and Mammalian EvolutionSemantic proximity Read ↗

Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis.Semantic proximity Read ↗

Stem Cell-Derived Exosomes with High Expression of PD-L1 as Nanotherapeutics in Rheumatoid Arthritis Model MiceSemantic proximity Read ↗

IL-1R/TLR2 through MyD88 Divergently Modulates Osteoclastogenesis through Regulation of Nuclear Factor of Activated T Cells c1 (NFATc1) and B Lymphocyte-induced Maturation Protein-1 (Blimp1)Semantic proximity Read ↗

Non-pyroptotic caspase-11 activity regulates osteoclastogenesis and pathological bone lossSemantic proximity Read ↗

ARTD1 regulates osteoclastogenesis and bone homeostasis by dampening NF-κB-dependent transcription of IL-1β.Semantic proximity Read ↗

The dynamic interplay between osteoclasts and the immune systemSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.