Article
Effects of vitamin D binding protein-macrophage activating factor (DBP-MAF) infusion on bone resorption in two osteopetrotic mutations.
Bone - 1 Jun 1995
Schneider G B, Benis K A, Flay N W, Ireland R A, Popoff S N
Abstract excerpt
Osteopetrosis is a heterogeneous group of bone diseases characterized by an excess accumulation of bone and a variety of immune defects. Osteopetrosis (op) and incisors absent (ia) are two nonallelic mutations in the rat which demonstrated these skeletal defects as a result of reduced bone resorption. Osteopetrotic (op) rats have severe sclerosis as a result of reduced numbers of osteoclasts which are...
Topics
- Animals
- Bone Marrow
- Bone Marrow Cells
- Bone Resorption
- Disease Models, Animal
- Macrophage-Activating Factors
- Microscopy, Electron
- Mutation
- Osteoclasts
- Osteopetrosis
- Oxidation-Reduction
