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Article

LRP1 Suppresses Bone Resorption in Mice by Inhibiting the RANKL-Stimulated NF-κB and p38 Pathways During Osteoclastogenesis.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 2018

Lu Di, Li Jianshuang, Liu Huadie, Foxa Gabrielle E, Weaver Kevin, Li Jie, Williams Bart O, Yang Tao

Abstract excerpt

Single-nucleotide polymorphisms in the LRP1 gene coding sequence are associated with low bone mass, and cell culture studies suggest that LRP1 plays a role in osteoblast proliferation and osteoblast-mediated osteoclastogenesis. However, the in vivo function of LRP1 in bone homeostasis has not been explored. In this work, we studied the osteoclast-specific role of LRP1 in bone homeostasis using a Ctsk-Cre;Lrp1f/f...

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Source

Identifiers

PMID: 29750835
DOI: 10.1002/jbmr.3469

Genes

LRP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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