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Article

Blimp1-mediated repression of negative regulators is required for osteoclast differentiation

28 Jan 2010

Abstract excerpt

Regulation of irreversible cell lineage commitment depends on a delicate balance between positive and negative regulators, which comprise a sophisticated network of transcription factors. Receptor activator of NF-kappaB ligand (RANKL) stimulates the differentiation of bone-resorbing osteoclasts through the induction of nuclear factor of activated T cells c1 (NFATc1), the essential transcription factor for...

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PMID: 20133620
DOI: 10.1073/pnas.0912779107

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