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Article

Estrogen regulation of trefoil factor 1 expression by estrogen receptor alpha and Sp proteins.

Experimental cell research - 1 Jan 2005

Sun Jian-Min, Spencer Virginia A, Li Lin, Yu Chen Hou, Yu Jenny, Davie James R

Abstract excerpt

Estrogen-responsive genes in human breast cancer cells often have an estrogen response element (ERE) positioned next to an Sp1 binding site. In chromatin immunoprecipitation (ChIP) assays, we investigated the binding of estrogen receptor alpha (ER), Sp1, and Sp3 to the episomal and native estrogen-responsive trefoil factor 1 (TFF1; formerly pS2) promoter in MCF-7 breast cancer cells. Mutation of the Sp site...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15541729
DOI: 10.1016/j.yexcr.2004.08.015

Genes

HDAC2
TFF1
HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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