Article
Regulation of Tissue Factor Gene Expression In Human Endometrium by Transcription Factors Sp1 and Sp3
1 Mar 2000
Abstract excerpt
Prior studies indicate that tissue factor (TF), the primary cellular initiator of hemostasis, is persistently up-regulated in human endometrial stromal cells (HESCs) undergoing progestin-induced decidualization in vivo and in vitro. The mechanism underlying progestin enhancement of TF mRNA and protein levels in these cells involves transcriptional activation of the TF gene. Transient transfections of HESCs with...
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