Article

Different SP1 binding dynamics at individual genomic loci in human cells

2020-12-19

Abstract excerpt

Using a tamoxifen-inducible time-course ChIP-seq approach, we show that the ubiquitous transcription factor SP1 has different binding dynamics at its target sites in the human genome that are not correlated with SP1 occupancy levels at those sites. While ~70% of SP1 binding sites are located in promoter regions, loci with slow SP1 binding turnover are enriched in enhancer and Polycomb-repressed regions. Unexpected...

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Literature Corpus work: 866646b6-73fc-56ad-a730-bd9ac1a7ab54
DOI: 10.1101/2020.12.18.423560

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