Article
Sp1 binding sites and an estrogen response element half-site are involved in regulation of the human progesterone receptor A promoter.
Molecular endocrinology (Baltimore, Md.) - 1 Jul 2000
Petz L N, Nardulli A M
Abstract excerpt
Progesterone receptor gene expression is induced by estrogen in MCF-7 human breast cancer cells. Although it is generally thought that estrogen responsiveness is mediated through estrogen response elements (EREs), the progesterone receptor gene lacks an identifiable ERE. The progesterone receptor A promoter does, however, contain a half-ERE/Sp1 binding site comprised of an ERE half-site upstream of two Sp1...
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