Article
Fos and Jun inhibit estrogen-induced transcription of the human progesterone receptor gene through an activator protein-1 site.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 2004
Petz Larry N, Ziegler Yvonne S, Schultz Jennifer R, Nardulli Ann M
Abstract excerpt
The progesterone receptor (PR) gene is activated by estrogen in normal reproductive tissues and in MCF-7 human breast cancer cells. Although it is typically thought that estrogen responsiveness is mediated through estrogen response elements (EREs), the human PR gene lacks a palindromic ERE sequence. We have identified an activating protein-1 (AP-1) site at +745 in the human PR gene that bound purified Fos and Jun...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.