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Article

Estrogen receptor alpha and Sp1 regulate progesterone receptor gene expression.

Molecular and cellular endocrinology - 28 Mar 2003

Schultz Jennifer R, Petz Larry N, Nardulli Ann M

Abstract excerpt

The progesterone receptor (PR) gene is induced by estrogen in reproductive and mammary tissues and in MCF-7 human breast cancer cells even though the human PR gene lacks an estrogen response element. We have identified a region from -80 to -34 in the PR gene that contains two Sp1 sites and confers estrogen responsiveness to a heterologous promoter in an estrogen and estrogen receptoralpha (ERalpha)-dependent...

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Identifiers

PMID: 12706304
DOI: 10.1016/s0303-7207(02)00415-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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