Article
Requirement of protein l-isoaspartyl O-methyltransferase for transcriptional activation of trefoil factor 1 (TFF1) gene by estrogen receptor alpha.
Biochemical and biophysical research communications - 6 Apr 2012
Park Jong Woo, Lee Jae Cheol, Ha Shin Won, Bang So Young, Park Eun Kyung, Yi Sang Ah, Lee Min Gyu, Kim Dae Sung, Nam Ki Hong, Yoo Ji Hee, Kwon So Hee, Han Jeung-Whan
Abstract excerpt
Lysine- and arginine-specific methyltransferases have been shown to act as either direct or secondary transcriptional co-activator of the estrogen receptor (ERα). However, little is known about the role of protein l-isoaspartyl O-methyltransferase (PIMT) on transcriptional regulation. Here, we show that PIMT acts as a co-activator for ERα-mediated transcription. Activation of the estrogen response element (ERE)...
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