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Article

Dual regulation of ets-activated gene expression by SP1.

Gene - 27 Mar 2003

Kelley Karen M M, Wang Huiquan, Ratnam Manohar

Abstract excerpt

The human folate receptor (hFR) type gamma gene is driven by a TATA-less promoter that uses a canonical Sp1 element for basal transcription. Using nuclear extract from 293 (human embryonic) cells, we mapped a second (non-canonical) Sp1 element to which Sp1 bound with a comparable affinity and which overlaps a functional ets binding site (EBS). Mutagenesis experiments revealed that the binding of ets to the EBS...

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PMID: 12706891
DOI: 10.1016/s0378-1119(03)00445-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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