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Article

Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase.

Nature cell biology - 1 Dec 2004

Kamura Takumi, Hara Taichi, Matsumoto Masaki, Ishida Noriko, Okumura Fumihiko, Hatakeyama Shigetsugu, Yoshida Minoru, Nakayama Keiko, Nakayama Keiichi I

Abstract excerpt

The cyclin-dependent kinase inhibitor p27(Kip1) is degraded at the G0-G1 transition of the cell cycle by the ubiquitin-proteasome pathway. Although the nuclear ubiquitin ligase (E3) SCF(Skp2) is implicated in p27(Kip1) degradation, proteolysis of p27(Kip1) at the G0-G1 transition proceeds normally in Skp2(-/-) cells. Moreover, p27(Kip1) is exported from the nucleus to the cytoplasm at G0-G1 (refs 9-11). These...

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PMID: 15531880
DOI: 10.1038/ncb1194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase.PMID 15531880Read ↗

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