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Article

CAND1 Promotes PLK4-Mediated Centriole Overduplication and Is Frequently Disrupted in Prostate Cancer

1 Sept 2012

Abstract excerpt

Centrosomes play a crucial role in the maintenance of genome stability by orchestrating bipolar mitotic spindle formation. The centrosome normally duplicates precisely once before mitosis in a process that is extensively regulated by protein degradation including SKP1-Cullin 1 (CUL1)-F-box (SCF) E3 ubiquitin ligase activity. The core SCF component CUL1 has recently been found to be required to suppress the...

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PMID: 23019411
DOI: 10.1593/neo.12580

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CAND1 Promotes PLK4-Mediated Centriole Overduplication and Is Frequently Disrupted in Prostate CancerPMID 23019411Read ↗

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