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Regulation of p27 Degradation and S-Phase Progression by Ro52 RING Finger Protein

1 Aug 2006

Abstract excerpt

Ubiquitin-mediated degradation of the cyclin-dependent kinase inhibitor p27 provides a powerful route for enforcing normal progression through the mammalian cell cycle. According to a current model, the ubiquitination of p27 during S-phase progression is mediated by SCF(Skp2) E3 ligase that captures Thr187-phosphorylated p27 by means of the F-box protein Skp2, which in turn couples the bound substrate via Skp1 to...

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PMID: 16880511
DOI: 10.1128/mcb.01630-05

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