Article
Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase.
Molecular and cellular biology - 1 Dec 2005
Wang I-Ching, Chen Yi-Ju, Hughes Douglas, Petrovic Vladimir, Major Michael L, Park Hyung Jung, Tan Yongjun, Ackerson Timothy, Costa Robert H
Abstract excerpt
The Forkhead box m1 (Foxm1) gene is critical for G(1)/S transition and essential for mitotic progression. However, the transcriptional mechanisms downstream of FoxM1 that control these cell cycle events remain to be determined. Here, we show that both early-passage Foxm1(-)(/)(-) mouse embryonic fibroblasts (MEFs) and human osteosarcoma U2OS cells depleted of FoxM1 protein by small interfering RNA fail to grow in...
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