Article
SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.
Cell - 26 Jul 1996
Bai C, Sen P, Hofmann K, Ma L, Goebl M, Harper J W, Elledge S J
Abstract excerpt
We have identified the yeast and human homologs of the SKP1 gene as a suppressor of cdc4 mutants and as a cyclin F-binding protein. Skp1p indirectly binds cyclin A/Cdk2 through Skp2p, and directly binds Skp2p, cyclin F, and Cdc4p through a novel structural motif called the F-box. SKP1 is required...
Topics
- Amino Acid Sequence
- Anaphase-Promoting Complex-Cyclosome
- Base Sequence
- Binding Sites
- Cell Cycle
- Cell Cycle Proteins
- Cyclins
- F-Box Proteins
- F-Box-WD Repeat-Containing Protein 7
- Fungal Proteins
- G1 Phase
- G2 Phase
- Gene Dosage
- Gene Expression
- Humans
- Ligases
- Mitosis
- Molecular Sequence Data