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Article

Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle.

Molecular and cellular biology - 1 Nov 2005

Hara Taichi, Kamura Takumi, Kotoshiba Shuhei, Takahashi Hidehisa, Fujiwara Kenichiro, Onoyama Ichiro, Shirakawa Masahiro, Mizushima Noboru, Nakayama Keiichi I

Abstract excerpt

KPC2 (Kip1 ubiquitylation-promoting complex 2) together with KPC1 forms the ubiquitin ligase KPC, which regulates degradation of the cyclin-dependent kinase inhibitor p27 at the G(1) phase of the cell cycle. KPC2 contains a ubiquitin-like (UBL) domain, two ubiquitin-associated (UBA) domains, and a heat shock chaperonin-binding (STI1) domain. We now show that KPC2 interacts with KPC1 through its UBL domain, with...

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Identifiers

PMID: 16227581
DOI: 10.1128/MCB.25.21.9292-9303.2005
PMCID: PMC1265808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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