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Article

Reversible dysfunction of wild-type p53 following homeodomain-interacting protein kinase-2 knockdown.

Cancer research - 15 May 2008

Puca Rosa, Nardinocchi Lavinia, Gal Hilah, Rechavi Gideon, Amariglio Ninette, Domany Eytan, Notterman Daniel A, Scarsella Marco, Leonetti Carlo, Sacchi Ada, Blandino Giovanni, Givol David, D'Orazi Gabriella

Abstract excerpt

About half of cancers sustain mutations in the TP53 gene, whereas the other half maintain a wild-type p53 (wtp53) but may compromise the p53 response because of other alterations. Homeodomain-interacting protein kinase-2 (HIPK2) is a positive regulator of p53 oncosuppressor function. Here, we show, by microarray analysis, that wtp53 lost the target gene activation following stable knockdown of HIPK2 (HIPK2i) in...

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Source

Identifiers

PMID: 18483253
DOI: 10.1158/0008-5472.CAN-07-6776

Genes

HIPK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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