Article
The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4.
Oncogene - 9 Jul 2009
Yamada D, Pérez-Torrado R, Filion G, Caly M, Jammart B, Devignot V, Sasai N, Ravassard P, Mallet J, Sastre-Garau X, Schmitz M L, Defossez P-A
Abstract excerpt
HIPK2 is a eukaryotic Serine-Threonine kinase that controls cellular proliferation and survival in response to exogenous signals. Here, we show that the human transcription factor ZBTB4 is a new target of HIPK2. The two proteins interact in vitro, colocalize and associate in vivo, and HIPK2 phosp...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.