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Article

Tumor Suppressor HIPK2 Regulates Malignant Growth via Phosphorylation of Notch1.

Cancer research - 15 Aug 2016

Ann Eun-Jung, Kim Mi-Yeon, Yoon Ji-Hye, Ahn Ji-Seon, Jo Eun-Hye, Lee Hye-Jin, Lee Hyun-Woo, Kang Hyeok-Gu, Choi Dong Wook, Chun Kyung-Hee, Lee Ji Shin, Choi Cheol Yong, Ferrando Adolfo A, Lee Keesook, Park Hee-Sae

Abstract excerpt

The receptor Notch1 plays an important role in malignant progression of many cancers, but its regulation is not fully understood. In this study, we report that the kinase HIPK2 is responsible for facilitating the Fbw7-dependent proteasomal degradation of Notch1 by phosphorylating its intracellular domain (Notch1-IC) within the Cdc4 phosphodegron motif. Notch1-IC expression was higher in cancer cells than normal...

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Source

Identifiers

PMID: 27335110
DOI: 10.1158/0008-5472.CAN-15-3310

Genes

HIPK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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