Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Negative regulation of beta4 integrin transcription by homeodomain-interacting protein kinase 2 and p53 impairs tumor progression.

Cancer research - 15 Jul 2009

Bon Giulia, Di Carlo Selene E, Folgiero Valentina, Avetrani Paolo, Lazzari Chiara, D'Orazi Gabriella, Brizzi Maria Felice, Sacchi Ada, Soddu Silvia, Blandino Giovanni, Mottolese Marcella, Falcioni Rita

Abstract excerpt

Increased expression of alpha(6)beta(4) integrin in several epithelial cancers promotes tumor progression; however, the mechanism underlying its transcriptional regulation remains unclear. Here, we show that depletion of homeodomain-interacting protein kinase 2 (HIPK2) activates beta(4) transcription that results in a strong increase of beta(4)-dependent mitogen-activated protein kinase and Akt phosphorylation,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytoplasm
Share to HCT116 Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histone Acetyltransferases

Share to HT29 Cells

Share to Integrin beta4

Share to Mitogen-Activated Protein Kinases

Share to p300-CBP Transcription Factors

Share to Proto-Oncogene Proteins c-akt

Source

Identifiers

PMID: 19567674
DOI: 10.1158/0008-5472.CAN-09-0244

Genes

HIPK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Negative regulation of beta4 integrin transcription by homeodomain-interacting protein kinase 2 and p53 impairs tumor progression.PMID 19567674Read ↗

p53 regulates cytoskeleton remodeling to suppress tumor progression.Semantic proximity Read ↗

Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cellsSemantic proximity Read ↗

Repression of the Antiapoptotic Molecule Galectin-3 by Homeodomain-Interacting Protein Kinase 2-Activated p53 Is Required for p53-Induced ApoptosisSemantic proximity Read ↗

Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis.Semantic proximity Read ↗

β4 Integrin Is a Transforming Molecule that Unleashes Met Tyrosine Kinase TumorigenesisSemantic proximity Read ↗

p53 inactivation upregulates p73 expression through E2F-1 mediated transcription.Semantic proximity Read ↗

Identification and characterization of the intercellular adhesion molecule-2 gene as a novel p53 target.Semantic proximity Read ↗

PINCH-1 Is an Obligate Partner of Integrin-linked Kinase (ILK) Functioning in Cell Shape Modulation, Motility, and SurvivalSemantic proximity Read ↗

IkappaB kinase beta promotes cell survival by antagonizing p53 functions through DeltaNp73alpha phosphorylation and stabilization.Semantic proximity Read ↗

Reversible dysfunction of wild-type p53 following homeodomain-interacting protein kinase-2 knockdown.Semantic proximity Read ↗

Mutant p53 drives invasion by promoting integrin recycling.Semantic proximity Read ↗

TAp73 suppresses tumor angiogenesis through repression of proangiogenic cytokines and HIF-1α activitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.