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Article

Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2.

The EMBO journal - 3 May 2006

Gresko Ekaterina, Roscic Ana, Ritterhoff Stefanie, Vichalkovski Anton, del Sal Giannino, Schmitz M Lienhard

Abstract excerpt

The serine/threonine kinase HIPK2 phosphorylates the p53 protein at Ser 46, thus promoting p53-dependent gene expression and subsequent apoptosis. Here, we show that DNA damaging chemotherapeutic drugs cause degradation of endogenous HIPK2 dependent on the presence of a functional p53 protein. Ea...

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Source

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Identifiers

PMID: 16601678
DOI: 10.1038/sj.emboj.7601077
PMCID: PMC1456935

Genes

HIPK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16601678-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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