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Article

A functional analysis reveals dependence on the anaphase-promoting complex for prolonged life span in yeast.

Genetics - 1 Oct 2004

Harkness Troy A A, Shea Kyla A, Legrand Charmaine, Brahmania Mayur, Davies Gerald F

Abstract excerpt

Defects in anaphase-promoting complex (APC) activity, which regulates mitotic progression and chromatin assembly, results in genomic instability, a hallmark of premature aging and cancer. We investigated whether APC-dependent genomic stability affects aging and life span in yeast. Utilizing replicative and chronological aging assays, the APC was shown to promote longevity. Multicopy expression of genes encoding...

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Source

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Identifiers

PMID: 15514051
DOI: 10.1534/genetics.104.027771
PMCID: PMC1448841

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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