Article
Genetic approaches to aging in budding and fission yeasts: new connections and new opportunities.
Sub-cellular biochemistry - 1 Jan 2012
Chen Bo-Ruei, Runge Kurt W
Abstract excerpt
Yeasts are powerful model systems to examine the evolutionarily conserved aspects of eukaryotic aging because they maintain many of the same core cellular signaling pathways and essential organelles as human cells. We constructed a strain of the budding yeast Saccharomyces cerevisiae that could monitor the distribution of proteins involved in heterochromatic silencing and aging, and isolated mutants that alter...
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