Sip2p and its partner snf1p kinase affect aging in S. cerevisiae.

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Article

Sip2p and its partner snf1p kinase affect aging in S. cerevisiae.

Genes & development - 1 Aug 2000

Ashrafi K, Lin S S, Manchester J K, Gordon J I

Abstract excerpt

For a number of organisms, the ability to withstand periods of nutrient deprivation correlates directly with lifespan. However, the underlying molecular mechanisms are poorly understood. We show that deletion of the N-myristoylprotein, Sip2p, reduces resistance to nutrient deprivation and shortens lifespan in Saccharomyces cerevisiae. This reduced lifespan is due to accelerated aging, as defined by loss of...

Topics

Carbon
DNA, Ribosomal
DNA-Binding Proteins
Fungal Proteins
Gene Expression Regulation, Fungal
Glucose
Mutation
Myristic Acid
Protein Serine-Threonine Kinases
Repressor Proteins
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Telomere
Trans-Activators

Source

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Identifiers

PMID: 10921902
PMCID: PMC316829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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