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Article

Mutations in the RAD27 and SGS1 genes differentially affect the chronological and replicative lifespan of yeast cells growing on glucose and glycerol.

FEMS yeast research - 1 Sept 2007

Ringvoll Jeanette, Uldal Lene, Roed Marie Aslaksen, Reite Karen, Baynton Kathy, Klungland Arne, Eide Lars

Abstract excerpt

The Sgs1 protein from Saccharomyces cerevisiae is a member of the RecQ helicases. Defects in RecQ helicases result in premature aging phenotypes in both yeasts and humans, which appear to be promoted by replicative stress. Yeast rad27 mutants also suffer from premature aging. As the human Rad27p and Sgs1p homologs interact, a similar interaction between the yeast proteins could be important for promoting...

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PMID: 17506834
DOI: 10.1111/j.1567-1364.2007.00248.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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