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Article

Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

G3 (Bethesda, Md.) - 1 Dec 2014

Sideri Theodora, Rallis Charalampos, Bitton Danny A, Lages Bruno M, Suo Fang, Rodríguez-López María, Du Li-Lin, Bähler Jürg

Abstract excerpt

Genetic factors underlying aging are remarkably conserved from yeast to human. The fission yeast Schizosaccharomyces pombe is an emerging genetic model to analyze cellular aging. Chronological lifespan (CLS) has been studied in stationary-phase yeast cells depleted for glucose, which only survive for a few days. Here, we analyzed CLS in quiescent S. pombe cells deprived of nitrogen, which arrest in a...

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Identifiers

PMID: 25452419
DOI: 10.1534/g3.114.014415
PMCID: PMC4291465

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