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Article

The anaphase promoting complex regulates yeast lifespan and rDNA stability by targeting Fob1 for degradation.

Genetics - 1 Mar 2014

Menzel Johannes, Malo Mackenzie E, Chan Cynthia, Prusinkiewicz Martin, Arnason Terra G, Harkness Troy A A

Abstract excerpt

Genomic stability, stress response, and nutrient signaling all play critical, evolutionarily conserved roles in lifespan determination. However, the molecular mechanisms coordinating these processes with longevity remain unresolved. Here we investigate the involvement of the yeast anaphase promoting complex (APC) in longevity. The APC governs passage through M and G1 via ubiquitin-dependent targeting of substrate...

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Identifiers

PMID: 24361936
DOI: 10.1534/genetics.113.158949
PMCID: PMC3948801

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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