Article
Apc10 and Ste9/Srw1, two regulators of the APC-cyclosome, as well as the CDK inhibitor Rum1 are required for G1 cell-cycle arrest in fission yeast.
The EMBO journal - 15 Sept 1998
Kominami K, Seth-Smith H, Toda T
Abstract excerpt
Many eukaryotic cells arrest the cell cycle at G1 phase upon nutrient deprivation. In fission yeast, during nitrogen starvation, cells divide twice and arrest at G1. We have isolated a novel type of sterile mutant, which undergoes one additional S phase upon starvation and, as a result, arrests a...
Topics
- Amino Acid Sequence
- Anaphase-Promoting Complex-Cyclosome
- Base Sequence
- Cell Cycle Proteins
- Cloning, Molecular
- Cyclin B
- Cyclin-Dependent Kinases
- Cyclins
- Enzyme Inhibitors
- Fungal Proteins
- G1 Phase
- Genes, Essential
- Genes, Fungal
- Genetic Complementation Test
- Ligases
- Molecular Sequence Data
- Mutation
- S Phase