Article
The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae.
Current biology : CB - 23 Apr 1998
Charles J F, Jaspersen S L, Tinker-Kulberg R L, Hwang L, Szidon A, Morgan D O
Abstract excerpt
BACKGROUND: Following chromosome segregation in anaphase, ubiquitin-dependent degradation of mitotic cyclins contributes to the exit from mitosis. A key step in this process is catalyzed by a ubiquitin-protein ligase known as the anaphase-promoting complex (APC), the regulation of which is poorly...
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