Article
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system.
Nature - 11 Nov 2004
Lu Xiaowei, Le Noble Ferdinand, Yuan Li, Jiang Quingjan, De Lafarge Benjamin, Sugiyama Daisuke, Bréant Christiane, Claes Filip, De Smet Frederik, Thomas Jean-Léon, Autiero Monica, Carmeliet Peter, Tessier-Lavigne Marc, Eichmann Anne
Abstract excerpt
Blood vessels and nerves are complex, branched structures that share a high degree of anatomical similarity. Guidance of vessels and nerves has to be exquisitely regulated to ensure proper wiring of both systems. Several regulators of axon guidance have been identified and some of these are also expressed in endothelial cells; however, the extent to which their guidance functions are conserved in the vascular...
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