Article
Netrin 1 directs vascular patterning and maturity in the developing kidney.
Development (Cambridge, England) - 15 Nov 2023
Honeycutt Samuel E, N'Guetta Pierre-Emmanuel Y, Hardesty Deanna M, Xiong Yubin, Cooper Shamus L, Stevenson Matthew J, O'Brien Lori L
Abstract excerpt
The intricate vascular system of the kidneys supports body fluid and organ homeostasis. However, little is known about how vascular architecture is established during kidney development. More specifically, how signals from the kidney influence vessel maturity and patterning remains poorly understood. Netrin 1 (Ntn1) is a secreted ligand that is crucial for vessel and neuronal guidance. Here, we demonstrate that...
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