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Article

Inhibition of endothelial cell apoptosis by netrin-1 during angiogenesis.

Developmental cell - 1 Apr 2009

Castets Marie, Coissieux Marie-May, Delloye-Bourgeois Céline, Bernard Laure, Delcros Jean-Guy, Bernet Agnès, Laudet Vincent, Mehlen Patrick

Abstract excerpt

Netrin-1 was recently proposed to play an important role in embryonic and pathological angiogenesis. However, data reported led to the apparently contradictory conclusions that netrin-1 is either a pro- or an antiangiogenic factor. Here, we reconcile these opposing observations by demonstrating that netrin-1 acts as a survival factor for endothelial cells, blocking the proapoptotic effect of the dependence...

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Source

Identifiers

PMID: 19386270
DOI: 10.1016/j.devcel.2009.02.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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