Article
Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development.
Developmental cell - 1 Jul 2003
Gu Chenghua, Rodriguez E Rene, Reimert Dorothy V, Shu Tianzhi, Fritzsch Bernd, Richards Linda J, Kolodkin Alex L, Ginty David D
Abstract excerpt
Neuropilin-1 (Npn-1) is a receptor that binds multiple ligands from structurally distinct families, including secreted semaphorins (Sema) and vascular endothelial growth factors (VEGF). We generated npn-1 knockin mice, which express an altered ligand binding site variant of Npn-1, and npn-1 conditional null mice to establish the cell-type- and ligand specificity of Npn-1 function in the developing cardiovascular...
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