Article

Netrin-1 binding to Unc5B regulates Blood-Retina Barrier integrity

2023-01-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The blood brain barrier (BBB) preserves neuronal function in the central nervous system (CNS) by tightly controlling metabolite exchanges with the blood. In the eye, the retina is likewise protected by the blood-retina barrier (BRB) to maintain phototransduction. We showed that the secreted guidance cue Netrin-1 regulated BBB integrity, by binding to endothelial Unc5B and re...

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Identifiers and source

Literature Corpus work: b2546ef1-e3f9-5d61-a090-345be6fdbbe3
DOI: 10.1101/2023.01.21.525006

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