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Article

Semaphorin 3E-Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism.

Genes & development - 1 Jul 2011

Kim Jiha, Oh Won-Jong, Gaiano Nicholas, Yoshida Yutaka, Gu Chenghua

Abstract excerpt

Blood vessel networks are typically formed by angiogenesis, a process in which new vessels form by sprouting of endothelial cells from pre-existing vessels. This process is initiated by vascular endothelial growth factor (VEGF)-mediated tip cell selection and subsequent angiogenic sprouting. Surprisingly, we found that VEGF directly controls the expression of Plexin-D1, the receptor for the traditional repulsive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neovascularization, Physiologic

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Source

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Identifiers

PMID: 21724832
DOI: 10.1101/gad.2042011
PMCID: PMC3134083

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