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Article

The netrin receptor UNC5B promotes angiogenesis in specific vascular beds.

Development (Cambridge, England) - 1 Feb 2008

Navankasattusas Sutip, Whitehead Kevin J, Suli Arminda, Sorensen Lise K, Lim Amy H, Zhao Jia, Park Kye Won, Wythe Joshua D, Thomas Kirk R, Chien Chi-Bin, Li Dean Y

Abstract excerpt

There is emerging evidence that the canonical neural guidance factor netrin can also direct the growth of blood vessels. We deleted the gene encoding UNC5B, a receptor for the netrin family of guidance molecules, specifically within the embryonic endothelium of mice. The result is a profound structural and functional deficiency in the arterioles of the placental labyrinth, which leads first to flow reversal in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18223200
DOI: 10.1242/dev.013623
PMCID: PMC2612632

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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