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Article

Autoinhibition of UNC5b revealed by the cytoplasmic domain structure of the receptor.

Molecular cell - 27 Mar 2009

Wang Rui, Wei Zhiyi, Jin Hao, Wu Hao, Yu Cong, Wen Wenyu, Chan Ling-Nga, Wen Zilong, Zhang Mingjie

Abstract excerpt

The cytoplasmic domains of UNC5 are responsible for its netrin-mediated signaling events in axonal migrations, blood vessel patterning, and apoptosis, although the molecular mechanisms governing these processes are unknown. To provide a foundation for the elucidation of the UNC5-mediated signaling mechanism, we determined the crystal structure of the cytoplasmic portion of UNC5b. We found that it contains three...

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Identifiers

PMID: 19328064
DOI: 10.1016/j.molcel.2009.02.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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