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Article

Inducible gene trapping with drug-selectable markers and Cre/loxP to identify developmentally regulated genes.

Molecular and cellular biology - 1 Nov 2004

Chen You-Tzung, Liu Pentao, Bradley Allan

Abstract excerpt

Gene trapping in mouse embryonic stem cells is an important genetic approach that allows simultaneous mutation of genes and generation of corresponding mutant mice. We designed a selection scheme with drug selection markers and Cre/loxP technology which allows screening of gene trap events that responded to a signaling molecule in a 96-well format. Nine hundred twenty gene trap clones were assayed, and 258 were...

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Identifiers

PMID: 15509795
DOI: 10.1128/MCB.24.22.9930-9941.2004
PMCID: PMC525470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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