Article
Mouse gene trap approach: identification of novel genes and characterization of their biological functions.
Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Jan 1998
Kitajima K, Takeuchi T
Abstract excerpt
The mouse gene trap strategy is an insertional mutagenesis involving an exogenous DNA, termed the trap vector, as a mutagen that produces a mutation in the mouse genome and a sequence tag to facilitate the isolation of the mutated genes. The trap vector consists of a reporter gene whose expression mimics that of the endogenous genes mutated and a selection marker that sorts cells bearing the inserted vector. Gene...
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