Confirmation of a major QTL influencing oral morphine intake in C57 and DBA mice using reciprocal congenic strains.

doi:10.1038/sj.npp.1300592

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Article

Confirmation of a major QTL influencing oral morphine intake in C57 and DBA mice using reciprocal congenic strains.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2005

Ferraro Thomas N, Golden Gregory T, Smith George G, Martin James F, Schwebel Candice L, Doyle Glenn A, Buono Russell J, Berrettini Wade H

Abstract excerpt

C57BL/6 (B6) and DBA/2 (D2) mice exhibit disparate behavior when tested for voluntary morphine intake in a two-bottle choice drinking paradigm with B6 mice consuming 10 times more drug than D2 mice. Previous genetic mapping studies identified a locus, Mop2, on the proximal part of chromosome 10 that explained over half of the genetic variance in this mouse model of opioid self-administration. We constructed a set...

Topics

Alleles
Animals
Brain Chemistry
Chromosome Mapping
Disease Models, Animal
Female
Food Preferences
Genetic Predisposition to Disease
Genetic Variation
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Inbreeding

Male

Mice

Mice, Congenic

Mice, Inbred C57BL

Mice, Inbred DBA

Morphine

Morphine Dependence

Source

Open in PubMed

Identifiers

PMID: 15508023
DOI: 10.1038/sj.npp.1300592

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