Article
Fine mapping of a major QTL influencing morphine preference in C57BL/6 and DBA/2 mice using congenic strains.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Nov 2008
Doyle Glenn A, Furlong Patrick J, Schwebel Candice L, Smith George G, Lohoff Falk W, Buono Russell J, Berrettini Wade H, Ferraro Thomas N
Abstract excerpt
C57BL/6J (B6) and DBA/2J (D2) mice differ in behaviors related to substance abuse, including voluntary morphine consumption and preference in a two-bottle choice paradigm. Two major quantitative trait loci (QTL) for morphine consumption and preference exist between these strains on chromosomes (Chrs.) 6 and 10 when the two-bottle choice involves morphine in saccharin vs quinine in saccharin. Here, we report the...
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