Congenic dissection of a major QTL for methamphetamine sensitivity implicates epistasis.

doi:10.1111/j.1601-183X.2012.00795.x

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Article

Congenic dissection of a major QTL for methamphetamine sensitivity implicates epistasis.

Genes, brain, and behavior - 1 Jul 2012

Bryant C D, Kole L A, Guido M A, Sokoloff G, Palmer A A

Abstract excerpt

We previously used the C57BL/6J (B6) × A/J mouse chromosome substitution strain (CSS) panel to identify a major quantitative trait locus (QTL) on chromosome 11 influencing methamphetamine (MA)-induced locomotor activity. We then made an F(2) cross between CSS-11 and B6 and narrowed the locus (Bayes credible interval: 79-109 Mb) which was inherited dominantly and accounted for 14% of the phenotypic variance in the...

Topics

Animals
Central Nervous System Stimulants
Chromosome Mapping
Epistasis, Genetic
Gene-Environment Interaction
Genetic Predisposition to Disease
Genotype
Methamphetamine
Mice
Mice, Congenic
Motor Activity
Quantitative Trait Loci

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Identifiers

PMID: 22487465
DOI: 10.1111/j.1601-183X.2012.00795.x
PMCID: PMC3691852

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