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Article

Verification of a genetic locus for methamphetamine intake and the impact of morphine.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Apr 2018

Eastwood Emily C, Eshleman Amy J, Janowsky Aaron, Phillips Tamara J

Abstract excerpt

A quantitative trait locus (QTL) on proximal chromosome (Chr) 10 accounts for > 50% of the genetic variance in methamphetamine (MA) intake in mice selectively bred for high (MAHDR) and low (MALDR) voluntary MA drinking. The µ-opioid receptor (MOP-r) gene, Oprm1, resides at the proximal end of Chr 10, and buprenorphine reduces MA intake in MAHDR mice. However, this drug has only partial agonist effects at MOP-r....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29127441
DOI: 10.1007/s00335-017-9724-5
PMCID: PMC5889309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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