Identification and functional significance of polymorphisms in the mu-opioid receptor gene (Oprm) promoter of C57BL/6 and DBA/2 mice.

doi:10.1016/j.neures.2006.03.005

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Article

Identification and functional significance of polymorphisms in the mu-opioid receptor gene (Oprm) promoter of C57BL/6 and DBA/2 mice.

Neuroscience research - 1 Jul 2006

Doyle Glenn A, Sheng X Rebecca, Schwebel Candice L, Ferraro Thomas N, Berrettini Wade H, Buono Russell J

Abstract excerpt

C57BL/6J and DBA/2J mice demonstrate differences in morphine preference when tested in a two-bottle choice paradigm. Quantitative trait loci (QTL) mapping suggested the proximal region of chromosome 10 was responsible for 41% of the observed genetic variance. The mu-opioid receptor (MOR) gene (Oprm) maps to this region and is a prime candidate for explaining the QTL. We hypothesized that variations in Oprm...

Topics

Animals
Brain
Brain Chemistry
Cell Line, Tumor
Disease Models, Animal
Gene Expression Regulation
Genetic Predisposition to Disease
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Molecular Sequence Data
Morphine
Morphine Dependence

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Narcotics

Neurons

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

Receptors, Opioid, mu

Source

Open in PubMed

Identifiers

PMID: 16644048
DOI: 10.1016/j.neures.2006.03.005

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