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Article

Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/6 and DBA/2 strains.

Life sciences - 1 Jan 1995

Belknap J K, Mogil J S, Helms M L, Richards S P, O'Toole L A, Bergeson S E, Buck K J

Abstract excerpt

A quantitative trait locus (QTL) was detected and mapped to proximal chromosome 10 near the markers Mpmv5 and D10Mit51 with a strong influence on morphine-induced analgesia in the BXD recombinant inbred (RI) strains and in an F2 cross (B6D2F2) between the BXD progenitor strains, C57BL/6 and DBA/2. A LOD score of 3.9 (p < .00002) was seen for analgesia using the hot plate assay. Naloxone Bmax was also associated...

Topics

Analgesia
Animals
Chromosome Mapping
Crosses, Genetic
Female
Gene Dosage
Genetic Markers
Genotype
Lod Score
Male
Mice
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred DBA

Morphine

Naloxone

Receptors, Opioid

Source

Identifiers

PMID: 7643715
DOI: 10.1016/0024-3205(95)02040-p

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7643715-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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