Article
Qualitative differences between C57BL/6J and DBA/2J mice in morphine potentiation of brain stimulation reward and intravenous self-administration.
Psychopharmacology - 1 Feb 2010
Elmer Greg I, Pieper Jeanne O, Hamilton Lindsey R, Wise Roy A
Abstract excerpt
RATIONALE: The C57BL/6J (C57) and DBA/2J (DBA) mice are the most common genotypes used to identify chromosomal regions and neurochemical mechanisms of interest in opioid addiction. Unfortunately, outside of the oral two-bottle choice procedure, limited and sometimes controversial evidence is available for determining their relative sensitivity to the rewarding effects of morphine. OBJECTIVES: The purpose of this...
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