Article
Quantitative trait loci influencing morphine antinociception in four mapping populations.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jul 2001
Bergeson S E, Helms M L, O'Toole L A, Jarvis M W, Hain H S, Mogil J S, Belknap J K
Abstract excerpt
Analgesia (pain reduction, or antinociception) is a classical and clinically important effect of morphine administration, and in rodent models sensitivity to morphine has been shown to be strongly influenced by genotype. For example, several studies have reported marked differences in morphine antinociception between the insensitive C57BL/6 (B6) and sensitive DBA/2 (D2) inbred mouse strains on the hot-plate...
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